Chemotherapy - Classification, Use And Work Mechanism Of Chemotherapy Drugs

Chemotherapy Definition - Chemotherapy is a way of treatment of disease by a parasite (bacteria, viruses, fungi, protozoa, and worm) and chemical medicines where the parasites are removed from the body without damaging the tissue.

sometimes cancer cells could be developed and transmitted ti other organisms such as bacteria, so that cancer drugs or sitostatica grouped into chemotherapy drugs.

Classification Chemotherapy

antibiotic
virustatic fungicides
sulfonamides and urinary tract antiseptic
medicines tuberculosis
leprosy drugs
malaria medicines
sitostatica
antiseptic and disinfectant

Work Mechanism Of Chemotherapy Drugs

chemotherapy mechanism of action is by inhibiting the synthesis of important materials from the parasite (bacteria, viruses, fungi, etc) for example :

1. cell wall : to the synthesis distributed so that the cell wall formed less than perfect and not strongly resists osmotic pressure of plasma, so that the cells rupture, for example :

a. the penicillin

b. the cephalosporins

2. cell membranes : molecular cell membrane lipoprotein of confused the synthesis making it more permeable so that important substances from cells can break out, for example :

a. nystatin

b. amphotericin

c. spiramisin

3. protein cells : for example :clotamphenicol, tetracycline, aminoglicosid, ervtromisin and linkomisin

4. acid-nucleic acids (DNA and RNA) : e. g. rifamin (RNA), nalidiksat acid (DNA)

5. antagonist : during rivals compete with substances that are essential for cell metabolism of the bacteria so that nutritional exchange stalled, such as sulfonamides, trimetoprim, PAS and INH.

The Use And Selection Of Chemotherapy Drugs

1. in heavy infection it is advisable to first do breeding bacteria that infect from bodily fluids such as blood, pus, or phlegm to determine the types of germs that infect and chemotherapy which are the most active?

2. in practice it is hard to do given the limitations of the facilities to let bacteria as well as quite a long waiting time

3. dose : the dose should be selected in such a high but not exceed the maximum dose so that the concentration of drug in the tissues exceeds the MIC (Minimum Inhibitory Concentration).

4. in measure frequency : depending on the plasma half-life (CA. 1/2) of the drug, if his short 1/2 ± then the granting of frequencies should be frequently (up to 4 times a day, but if his long 1/2 ± then the granting of frequencies can be reduced (up to once a day).

5. long therapy : should be long enough to avoid a recurrence of the disease, usually up to 3-4 days after the symptoms of the disease are missing. for certain cases required a longer therapy, for example : typhoid, tuberculosis, endocarditis and leprosy.

Chemotherapy - Classification, Use And Work Mechanism Of Chemotherapy Drugs