Non- Narcotic Analgesic Drugs And Working Mechanism Of Non-Narcotic Analgesic

Non-Narcotic Analgesic

Non-Narcotic Analgesic are often referred to as the peripheral analgesic, because it works in peripheral and does not affect the central nervous system (CNS), did not lose consciousness and does not lead to addiction to addictive.

Anti-Pyre-tic

all peripheral works analgesic has anti-pyretic, namely lowering the temperature of the body in a State of fever, then the drug is also known as analgesic anti-pyretic.

Anti-F logistic

except antipirin, paracetamol, fenasitin and glafenenin, all analgesic peripheral also has the effect of anti-inflammation (anti-f logistic)

Mechanism Of Non-Narcotic Analgesic

the non-narcotic analgesic drugs is working as anti pain by inhibiting an enzyme work oxygenate on the siklum formation of aracodinat acid conversation so Prostagladin be disturbed or inhibited Prostagladin.

Prostagladin serves as mediators of pain that will be released when cells undergo damage due to either mechanical stimulation or due to chemical stimulation.

anti-pyretic effect of the drugs is also thought to be associated with the inhibition of the formation of Protagladin, due to an increase in body temperature in the state of pathological begins with the relase of endogenous substances or pirogen cytokines cytokine release which is stimulated by prostagladin.

anti-g logistic effect of the drug is a think intimately connected with the formation of the leukotrianes, substances which are not all analgesic peripheral can inhibit the formation of such substances so as not to have anti-inflammatory effects.

Classifications Of Peripheral Analgesic

Have Salicylate :

sodium salicylate (asetosal)
salisilamid

P-aminophenols have :

fenasetin
paracetamol

Have Pirazolon :

antipirin
aminofenazon
antalgin
fenilbutazon

Have Antranilat :

glafenin
mefenamic acid
nifluminat acid

1. Acetyl Salicylic Acid

acetyl salicylic acid or better known as asetosal has the effect of anti-pyretic, analgesic, anti f-logistic and which strong, so widely used in the treatment. asetosal also have the effect of inhibiting the formation of platelet agregasio and tomboxan (blood clothing) so it is often used to prevent the second attack on the patient's cardiac infarct.

The Use Of Acetyl Salicylic Acid Or Astosal

acetyl salisylic acid or asetosal is often used to treat fever, influenza, headaches, muscle pain, joint pain, toothache, and rheumatism.

Acetyl Salicylic Acid Side Effects

side effect that often occurs in the irritation of the mucous of the stomach, causing stomach ulcers. to reduce such effects can be used to together with antacids. other side effect can cause hearing loss and respiratory disorders.

Dose : day 3-4 time @ 500 mg after meal

2. Salicylamide

salicylamid is derivative of salicylic acid with analgesic properties are weaker compared to asetosal. on the wall of the bowel undergo decomposition that is large enough, so that its effectiveness is doubtful, and often cause digestive disorders. the use and side effects are almost the same as asetosal.

Dose : 4 time a day @ 1 gr.

3. Metilcalycilat

metilcalycilat is a derivative of salicylate in the form of astringent liquid with a characteristic smell, can be obtained from the leaves and rootd of plants (scented root) or made of synthetics. which worked closely with the other salicylate and on-premises deployment quick skin is resorbed, so widely used in the ointment or liniment for reducing pain.

4. Fenasetin

Fenasetin is asetanilida, have benefits analgesic have anti-pyretic and not have the effect of anti-inflammation in the liver, these drugs will be metabolized and overhauled to become asetanilida and paracetamol, and expelled through the urine.

Fenasetin Side Effects

side effects caused by fenasetin is the head pain, a kind of euphoria, disorders of the blood, and on the use of long may damage the kidneys can even damage the liver.

5. Paracetamol, Acetaminophen

paracetamol is the metabolite of fenasetin with analgesic anti-pyretic properties equal to the parent compound.

Side Effects Of Paracetamol

relatively light, especially not nefrotoxic and not cause euphoria and psychic dependence. analgesic use as antipyretic effects with anti-pyretic more dominant.

Dose : 4-6 times a day @325-650 mg.

6 Antalgin, Dipiron Metampiron

antagin is a analgesic derivative of pirazolon with analgesic anti-pyretic efficiency-antiinflammation. in its use. is often combined with clordiazepoksida and diazepam useful reinforcing the effect.

Side Effects Of Antagin, Dipiron, Metampiron

the side effects of these medications is paramount agranulocytosis, thrombocytopenia, and anemia of a plastic.

The Use Of Antalgin, Dipiron, and Metampiron

antalgin- anti-inflammatory because the effect of anti-pyretic weaker than paracetamol.

Dose : 3 times a day @500-100 mg.

7. Fenilbutazon

the pirazolon used to treat diseases of the pirai (gout) rheumatoid arthritis, acute and other joint disorders.

Dose :

pirai (gout) : 3-4 times a day @ 200 mg

rheumatism : 3-4 times a day @100 mg

8. Mefenamic Acid

mefenamic acid is have antranilat with the effect of anti-pyretic and analgesic anti-inflammation

Side Effects Od Mefenamic Acid

common side effects are stomach disorders-bowel (dispesia, diarrhea), skin reactions (erythema) and broncocontriction.

Dose : 2-3 times a day @250-500 mg

9. Diclofenak

diclofenak is fenilasetat have analgesic - anti f logistic with the effect most strongly
Na-diclofenak : analgesic and anti-f-logistic
K-Diclopenak : analgesic and anti inflammation

Dose : 2-3 times a day @25-50 mg

10. Ibuprofen

ibuprofen include NSID with anti-inflammatory effects, as well as being analgesic. the reabsorb from gut good effects with fast, in 1-2 hours absorbed 99%. ibuprofen can be swallowed up by the time empty stomach in order to obtain a fast effect. have ibuprofen, flurbiprofen,ketaprofen, indoprofen, tioprofenat acid.

Dose : 3-4 times a day @400 mg

11. Piroxykam

piroxikam effect anti-inflammation, anti-pyretic and analgesic are powerful and can be used for an attack of gout common side effect of gastric-intestinal disorders namely.

Dose : 2 times a day @10-20 mg.

Non- Narcotic Analgesic Drugs And Working Mechanism Of Non-Narcotic Analgesic